Dr. Syafiqah Saidin

Niche Area : Biomaterials

Holding an academic position of senior lecturer at School of Biomedical Engineering & Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia Johor Bahru (UTM JB), Malaysia and a research position of deputy director at IJN-UTM Cardiovascular Engineering Centre, Institute of Human Centered Engineering, UTM JB. Conducting her research under Health & Wellness research alliance. Member of several professional bodies including Institute of Materials, Minerals & Mining (IOM3), Graduate Engineer in Malaysia Board of Engineer (BEM), American Chemical Society Malaysia section (ACS), IEEE Malaysia section, IEEE-EMBS Medicine & Biology Society, Institute of Materials Malaysia (IMM). Also a certified Human Resources and Development Fund (HRDF) trainer with a certification in Good Clinical Practice (GCP), Higher Education Teaching and Cardiopulmonary Resuscitation (CPR) Practice. Research interests are localised on biomaterials (membrane, hydrogel, implant coating and scaffold) with the specification on bioactive materials and antibacterial materials. The development and fabrication of biomaterials are intended for bone, cardiovascular and skin applications. In addressing the problem of infection, inorganic materials such as silver and organic materials such as chlorhexidine, honey and M. oleifera are incorporated into biomaterials. While in addressing cells & tissues impairment, hydroxyapatite, ginseng, honey, collagen, elastin, chitosan, everolimus and Factor 7 biomolecules are adopted. The project on chlorhexidine antibacterial coating has been awarded silver medal in PECIPTA 2019 and bronze medal in INATEX 2018. The high impact factor publications of this project also have gained great attention from YTY Sdn. Bhd., a medical glove company.

Recent Projects

1. Antibacterial chlorhexidine coating

2. Cardiovascular membrane of PU/elastin/chitosan

3. Ginseng encapsulated PLGA stent coating

4. Honey hydrogel patch

5. HA grafted PLA bone scaffold

6. Everolimus grafted biodegradable PLA stent scaffold

7. Bioactive HA-Collagen Coating 

Collaborators

1. Institut Jantung Negara (IJN)

2. Universiti Tun Hussein Onn Malaysia (UTHM)

3. Muhammadiyah University of Riau, Indonesia

4. Laval University, Canada

Selected Publications

  1. F. Mohd Yusoff, N. H. Abu Kasim, W. H. Himratul-Aznita, S. Saidin, K. Genasan, T. Kamarul and Z. Radzi, “Physicochemical, antibacterial and biocompatibility assessments of silver incorporated nano-hydroxyapatite synthesized using a novel microwave-assisted wet precipitation technique”, Materials Characterization, vol. 178, pp. 111169, 2021.
  2. Sheikh, T. Tian Swee, S. Saidin, A. Yahya, S. Ahmad Malik, J. S. Sin Yin and T. Foh Thye, “Bacterial disinfection and cell assessment post ultraviolet-C LED exposure for wound treatment”, Medical & Biological Engineering & Computing, vol. 59, pp. 1055–1063, 2021.
  3. A. Jumat, P. Chevallier, D. Mantovani, F. Copes, A. I. Abd Razak and S. Saidin, “Three-dimensional printed biodegradable poly(l-lactic acid)/(poly(d-lactic acid) scaffold as an intervention of biomedical substitute”, Polymer-Plastics and Technology Materials, vol. 60, pp. 1005–1015, 2021.
  4. Asiri, S. Saidin, M. H. Sani and R. H. Al-Ashwal, “Epidermal and fibroblast growth factors incorporated polyvinyl alcohol electrospun nanofibers as biological dressing scaffold”, Scientific Reports, vol. 11, pp. 5634, 2021.
  5. Saidin, M. A. Jumat, N. A. A. Mohamad Amin and A. S. Saleh Al-Hammadi, “Organic and inorganic antibacterial approaches in combating bacterial infection for biomedical application”, Materials Science & Engineering C, vol. 118, pp. 1–18, 2021.
  6. A. Jumat, N. S. Zahidin, M. A. A. Zaini, N. A. Fadzil, H. Nur and S. Saidin, “Incorporation of Acalypha indica extract in polyvinyl alcohol hydrogels: Physico-chemical, antibacterial and cell compatibility analyses”, Jurnal Teknologi, vol. 83, pp. 57–65, 2021.
  7. H.-Y. Li, H.-C. Lin, B.-J. Huang, A. Z. K. Lo, S. Saidin and C.-H. Lai, “Size preferences uptake of glyco-silica nanoparticles to MDA-MB-231 cell”, Langmuir, vol. 36, pp. 11374–11382, 2020.
  8. K. Lukman and S. Saidin, “Effects of different polyaniline emeraldine compositions in electrodepositing ginsenoside encapsulated poly(lactic-co-glycolic acid) microcapsules coating: Physico-chemical characterization and in-vitro evaluation”, Journal of Biomedical Materials Research Part A, vol. 108, pp. 1171–1185, 2020.
  9. K. Lukman, R. H. Al-Ashwal, N. Sultana and S. Saidin, “Electrodeposition of ginseng/polyaniline encapsulated poly(lactic-co-glycolic acid) microcapsule coating on stainless steel 316L at different deposition parameters”, Chemical and Pharmaceutical Bulletin, vol. 67, pp. 445–451, 2019.
  10. K. Lukman, R. H. Al-Ashwal and S. Saidin, “Emerging of cardiovascular metal stent: Utilisation of drugs in preventing complications following stent implantation”, Malaysian Journal of Fundamental and Applied Sciences, vol. 15, pp. 225–231, 2019.
  11. Mohd Daud, R. H. Al-Ashwal, M. R. Abdul Kadir and S. Saidin, “Polydopamine-assisted chlorhexidine immobilization on medical grade stainless steel 316L: Apatite formation and in vitro osteoblastic evaluation”, Annals Anatomy, vol. 220, pp. 29–37, 2018.
  12. Y. Foong, M. S. A. Hamzah, S. I. A Razak, S. Saidin and N. H. M. Nayan, “Influence of poly(lactic acid) layer on the physical and antibacterial properties of dry bacterial cellulose sheet for potential acute wound healing materials”, Fibers and Polymers, vol. 19, pp. 263–271, 2018.
  13. Mohd Daud, N. A. Masri, N. A. N. Nik Malek, S. I. Abdul Razak and S. Saidin, “Long-term antibacterial and stable chlorhexidine-polydopamine coating on stainless steel 316L”, Progress in Organic Coatings, vol. 122, pp. 147–153, 2018.
  14. Tapsir, F. H. Jamaludin, B. Pingguan-Murphy and S. Saidin, “Immobilisation of hydroxyapatite-collagen on polydopamine grafted stainless steel 316L: Coating adhesion and in-vitro cells evaluation”, Journal of Biomaterials Applications, vol. 32, pp. 987–95, 2018.
  15. Abdul Hanan, A. K. Nasution, R. Hussain and S. Saidin, “Fabrication of poly(lactic-co-glycolic acid)/calcium phosphate bone cement composite: Synthesization of calcium phosphate from crab shells”, Jurnal Teknologi, vol. 80, pp. 103–109, 2018.
  16. S. Zahidin, S. Saidin, R. M. Zulkifli, I. I. Muhamad, H. Ya’akob and H. Nur, “A review of Acalypha indica L. (Euphorbiaceae) as traditional medicinal plant and its therapeutic potential”, Journal of Ethnopharmacology, vol. 207, pp. 146–173, 2017.
  17. N. Saarani, J. –T. Kalitheerta, N. Shahab, H. Hermawan and S. Saidin, “Antibacterial efficacy of triple-layered poly(lactic-co-glycolic acid)/nanoapatite/lauric acid guided bone regeneration membrane on periodontal bacteria”, Dental Materials Journal, vol. 36, pp. 1–5, 2017.
  18. Z.Miswan, F. A. Abd. Majid, L. Mun Fai, S. Saidin and H. Hermawan, “Drug-eluting coating of ginsenoside Rg1 and Re incorporated poly(lactic-co-glycolic acid) on stainless steel 316L using dip coating technique: Coating optimization and drug release analysis”, International Journal of Pharmaceutics, vol. 515, pp. 460–466, 2016.
  19. N. Mohd Daud, I. Fithriyana, N. A. N. Nik Malek, H. Hermawan and S. Saidin, “Immobilization of antibacterial chlorhexidine on stainless steel using crosslinking polydopamine film: Towards infection resistant medical devices”, Colloids and Surfaces B: Biointerfaces, vol. 145, pp. 130–139, 2016.
  20. Z. Tapsir and S. Saidin, “Synthesis and characterization of collagen-hydroxyapatite immobilized on polydopamine grafted stainless steel”, Surface & Coatings Technology, vol. 285, pp. 11–16, 2016.
  21. M. F. Md Nor, M. R. Abdul Hanan, Z. N. Zamal, N. M. Daud, Z. Tapsir and S. Saidin, “Synthesis of calcium phosphate at different pH condition”, Journal of Advanced Research in Materials Science, vol. 13, pp. 11–15, 2015.
  22. J. Amer Nordin, D. H. Prajitno, H. Nur and H. Hermawan, “Structure-property relationships of iron-hydroxyapaite ceramic matrix nanocomposite fabricated using mechanosynthesis method”, Materials Science & Engineering C,vol. 51, pp. 294–299, 2015.
  23. A. A. Mustafa, J. P. Matinlinna, S. Saidin and M. R. Abdul Kadir, “The influence of experimental silane primers on dentin bond strength and morphology: A laboratory and finite element analysis study”, The Journal of Prosthetic Dentistry, vol. 112, pp. 1498–1506, 2014.
  24. A. A. Madfa, M. R. Abdul Kadir, J. Kashani, S. Saidin, E. Sulaiman, J. Marhazlinda, R. Rahbari, B. J. J. Abdullah, H. Abdullah and N. H. Abu Kasim, “Stress distributions in maxillary central incisors restored with various types of post materials and designs”, Medical Engineering & Physics, vol. 36, pp. 962–967, 2014.
  25. S. Saidin, P. Chevallier, M. R. Abdul Kadir, H. Hermawan and D. Mantovani, “Polydopamine as an intermediate layer for silver and hydroxyapatite immobilisation on metallic biomaterials surface”, Materials Science & Engineering C,vol. 33, pp. 4715–4724, 2013.
  26. S. Saidin, M. R. Abdul Kadir, N. H. Abu Kasim and E. Sulaiman, “Effects of different implant–abutment connections on micromotion and stress distribution: Prediction of microgap formation”, Journal of Dentistry, vol. 40, pp. 467–474, 2012.

    People

    Postgraduate Supervision

    PHD

    • Mohamad Amin Jumat – Immobilisation of Everolimus on Biodegradable Poly(D-lactic acid) / Poly(L-lactic acid) Scaffold Mediated by Polydopamine Intermediate Layer
    • Madeeha Sadia – ​Incorporation of Antibacterial Moringa oleifera Leaves Extract into Electrospun Polycaprolactone Nanofibres for Skin Regeneration
    • Ala Abobakr Al-Dubai – Nucleation of Hydroxyapatite on Polydopamine Grafted Three-Dimensional Printed Poly(lactic acid) Micro-Porous Scaffold for Bone Grafting
    • Rathosivan Gopal – Immobilisation of Factor VIIa on Polydopamine Grafted Polycaprolactone Membrane for Cardiac Bleeding Application
    • Amnah Ismail A Asiri – Double Layer Polyvinyl Alcohol Skin Scaffold Incorporated with Fibroblast and Endothelial Growth Factors
    • Amirul Ridhwan Sazali – Effect on Mechanical Milling Time on Preparation on Characteristic, Magnetic Behaviour and In-vivo Study of Hematite-Hydroxyapatite Nanocomposite

    MASTER

    • Thiviya Selvaras – Degradation Analysis and Blood Compatibility on Electrospun Membrane of Polyurethane Blended Chitosan/Elastin for Cardiovascular Graft
    • Thasleema Parveen Malick – Differentiation of Physico-Chemical and Cytotoxicity Properties Between Elastin/Chitosan/Polyurethane Electrospun Membrane and Commercialised Vascular Membranes

    Alumni

    PHD

      • Siti Khadijah Lukman – Ginseng Encapsulated Poly(lactic-co-glycolic acid)/Polyaniline Microcapsules Coating on Stainless Steel 316L Using Electrodeposition Technique (2021)
      • Mohd Izzat Hassan – Poly(hydroxybutyrate-co-hydroxyvalerate)/Poly(lactic-co-glycolic acid)/Strontium Hydroxyapatite/Shikonin Nanofiber Scaffold (2019)
      • Nurizzati Mohd Daud – Immobilisation of Antibacterial Chlorhexidine on Polydopamine Grafted Stainless Steel 316L for Osseointegrated Implant (2019)
      • Norsyahiran Zahidin – Optimisation of Anti-Oxidant Phytochemical Extraction of Acalypha indica for Therapeutic Application (2019)
      • Sameen Ahmed Malik – Effectiveness of Multivariate Parameters on Medical Device Disinfection using Pulsed Irradiated Simultaneously-Coupled Triadic Wavelength UV-LEDs (2020)
      • Jamillah Amer Nordin – Multifunctional Bovine Hydroxyapatite/Alpha-Ferum Oxide Nanocomposite Material using Mechanosynthesis (2019)
      • Ahmad Kafrawi Nasution – Penetap Tulang Besi Tahan Karat Terbiodegradasi Menggunakan Kaedah Kimpalan Geseran (2017)

    MASTER

      • Alex Lo Zhen Kai – Double Layer Materials Consisting of Poly(lactic-co-glycolic Acid) / Cellulose Stingless Bee Honey Hydrogel for Biomedical Application (2021)
      • Somyah Ali Alshamrani – Fabrication and Characterization Analyses on Polyurethane Electrospun Nanofibers Incorporated with Chitosan/Elastin for Cardiovascular Grafting (2021)
      • Zafirah Tapsir – Incorporation of Bioactive Collagen Type I and Biomineralised Hydroxyapatite on Polydopamine Grafted Stainless Steel (2018)
      • Mohd Amirul Aizat Zaini – Antibacterial Analysis on Acalypha indica Hydrogel for Wound Healing (2018)
      • Zulaika Miswan – Physico-Chemical Properties of Stainless Steel 316L Coated with Ginseng-Poly(lactic-co-glycolic acid) for Stent Application (2017)
      • Nur Najiha Saarani – Antibacterial and Cytocompatibility Analyses on Triple Layered Poly(lactic-co-glycolic acid)/Nanoapatite/Lauric Acid Composite Membrane (2016)
      • Ng Boon Sing – Evaluation on Modified Electrochemical Noise Measurement for Degradation Monitoring of Biodegradable Metals (2016)
      • Jahanzeb Sheikh – Wound Bacterial Disinfection and Cell Assessment Post Ultraviolet-C Exposure (2019)
      • Mohd Syahir Anwar Hamzah – Evaluation of Poly(lactic acid)/Pectin Scaffold Potential for Tissue Engineering Application (2018)
      • Mohd Amirul Aizat Zaini – Antibacterial Analysis on Acalypha indica Hydrogel for Wound Healing (2018)
      • Siti Norhayati Md. Yassin – Study on Salivary Protein and Brain Responses during Emphathetic Pain Reception (2018)
      • Murni Nazira Sarian – Cytotoxicity Assessment of Novel Zn Alloys for Bone Application (2014)

    Practical Student

    • Anri Yoshida – Tokyo University of Agriculture and Technology, Japan (2018)
    • Dismarni – Muhammadiyah University of Riau, Indonesia (2018)
    • Jessy Octavia Harahap – Muhammadiyah University of Riau, Indonesia (2018)
    • Intan Liyana Rosli – Kolej Kemahiran Tinggi MARA Ledang, Malaysia (2018)
    • Nur Arina Rosnan – Kolej Kemahiran Tinggi MARA Ledang, Malaysia (2018)
    • Gabriella Eldreen Jogia – Swiss German University, Indonesia (2017)
    • Nurul Nadia Roslan – International Islamic University Malaysia, Malaysia (2016)

    For More Info

    Research Keyword :Biomaterials; Antibacterial; Bioactive; Surface characterisation

    Lab : 

    – Biomedical Sciences Lab – Biocompatibility Lab

    Email : syafiqahs@utm.my

    Scholar Publication Link : http://scholar.google.com.my/citations?user=QugUmy0AAAAJ&hl=en

    Personal Website : https://people.utm.my/syafiqahsaidin/